[BrianG]

Shouldn't. That only downside is that you have less "snap" when you punch the throttle. When set high, the ESC integrates the throttle signal. So, even though you mash the throttle instantly, the ESC will internally ramp up the throttle slower over time. This can help reduce the huge current spike if the motor is trying to move a heavy vehicle from 0mph to 40mph in a split second.