I run the same exact motor with a Quark 33 on 3s lipo in my Vendetta ST. The drivetrain holds up fine, but that was after I did a bit of shimming (I shimmed the internal differential gears that are pressed on to the outdrives). The outdrive gears have very shallow teeth, so it's easy to strip them if you accidentally spin out a few times. I simply placed very thin (.1mm) shims on the outdrives, then pressed the gears on to get the mesh ever so slightly tighter.
Drivetrain handles it just fine. I'm geared with a 15 tooth pinion and the stock spur; the car is probably only doing a modest 35-40mph, but it's a squirrely little bugger. I can't even imagine it at 60+!