Personally, I'd go series. That way you never have to worry about accidentally putting 2 x 4S packs in series and killing the ESC. Then you also have the option of buying hardcased packs as well.
I was opting for series just because it would be way cheaper.. you can get a 2s 5000 zippy for 40 bucks.. but didn't know if there was an advantage over one or the other..