is Final gear ratio important when using slip diff?

[superek4]

Hi,

I m driving a x2 CRT final gear ratio is 16.25 for gp.48spur n 14clutch.

I m using a 50slip diff n gear ratio is out about 17.31. Spur 50 n 13pinion on 6s 5000 using 1600kv

If I use 4s the final gear ratio is 11.84.spur 50 n 19 pinion on 1600kv

Does it really matters?