Possible brushless setup (your thoughts)

I would like to set a price for the two setups...

Setup 1:

HW80 esc
Medusa __mm motor???
Zippy 4s
RCM mount

Setup 2:

Hw150/mmm esc
Medusa __mm motor????
Zippy 5s (probably lower mah then the 4s would be)
RCM mount

Which setup would run cooler? with the 4s i would get more runtime, but the 5s i will get more power. if I can get a nice 4s setup for considerably cheaper, i will have no problem with the power. But if it's not much more, then why not? Don't know how many mm/kv motor to run on the setups. With 5s i will probably run the MMM, but the Hw150 is still up for grabs.